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CS-W001157 4
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4-Methyl-1-piperazinepropanoic acid

  • CAS No. 55480-45-0

  • Cat. No. CS-0205907
  • Purity≥97%
  • MDL No.MFCD00513444

*For research and further manufacturing use only, not for direct human use.

4-Methyl-1-piperazinepropanoic acid|CS-0205907

Structure of 55480-45-0

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General Information

  • CAS No. 55480-45-0
  • Cat. No. CS-0205907
  • Purity ≥97%
  • MDL No. MFCD00513444
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₆N₂O₂
  • Molecular Weight 172.22
  • Synonym(s) 3-(N-METHYLPIPERAZINE)-PROPAN-1-OIC ACID HYDROCHLORIDE SALT
  • SMILES CN1CCN(CCC(=O)O)CC1

Description

4-Methyl-1-piperazinepropanoic acid features a sterically hindered piperazine core paired with a methyl-substituted propanoic acid chain, enhancing solubility and metabolic stability. This structural combination enables robust integration into peptide conjugates and bioactive scaffolds under standard conditions.

Application

4-Methyl-1-piperazinepropanoic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive molecules through its pendant piperazine and carboxylic acid functionalities. The molecule exhibits good bench stability and facilitates straightforward derivatization via amide coupling or esterification, supporting efficient route optimization in API development. Its functional group tolerance supports integration into diverse heterocyclic scaffolds and peptide-like architectures.

Synthesis

  • Route1

    References

    • European Journal of Medicinal Chemistry, , vol. 46, # 6 p. 2224 - 2235
  • Route2
    • Ethyl 3-(4-methylpiperazin-1-yl)propanoate|CS-0317278
      7148-05-2
    • ~%
    • In-stock
      4-Methyl-1-piperazinepropanoic acid|CS-0205907
      55480-45-0

    References

    • European Journal of Medicinal Chemistry, , vol. 46, # 6 p. 2224 - 2235

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P302+P352-P304+P340

Quality Control

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Computational Chemistry Data

  • TPSA   43.78
  • LogP   -0.2915
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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