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CS-W001157 4
Total: USD 88.00

(R,R)-BaryPhos

  • CAS No. 2416226-97-4

  • Cat. No. CS-0119123
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(R,R)-BaryPhos|CS-0119123

Structure of 2416226-97-4

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General Information

  • CAS No. 2416226-97-4
  • Cat. No. CS-0119123
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₂H₄₅O₄P
  • Molecular Weight 524.67
  • Synonym(s) 2-((2R,3R)-3-(tert-butyl)-4-(3,5-dicyclopentyl-2,6-dimethoxyphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphol-2-yl)propan-2-ol
  • SMILES CC(C)(O)[C@H](O1)[P@](C(C)(C)C)C(C1=CC=C2)=C2C3=C(OC)C(C4CCCC4)=CC(C5CCCC5)=C3OC

Description

(R,R)-BaryPhos is a chiral diphosphine ligand featuring a rigid, electron-rich backbone that enhances enantioselectivity in palladium-catalyzed cross-coupling reactions. Its sterically defined architecture enables high stereoselectivity and catalyst stability under standard conditions, delivering consistent performance in asymmetric synthesis workflows.

Application

(R,R)-BaryPhos serves as a highly effective chiral diphosphine ligand in palladium-catalyzed cross-coupling reactions, enabling efficient C–C bond formation with excellent enantioselectivity. Its robust bench stability and broad functional group tolerance facilitate reliable performance in asymmetric Suzuki-Miyaura and Negishi couplings, making it a practical choice for the synthesis of enantiomerically enriched biaryl and alkenyl scaffolds in medicinal chemistry and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   47.92
  • LogP   8.0811
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   6

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