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CS-W001157 4
Total: USD 88.00

(S,S)-BaryPhos

  • CAS No. 2416226-68-9

  • Cat. No. CS-0119122
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(S,S)-BaryPhos|CS-0119122

Structure of 2416226-68-9

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General Information

  • CAS No. 2416226-68-9
  • Cat. No. CS-0119122
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₂H₄₅O₄P
  • Molecular Weight 524.67
  • Synonym(s) 6-dimethoxyphenyl)-2
  • SMILES CC(C)(O)[C@@H](O1)[P@@](C(C)(C)C)C(C1=CC=C2)=C2C3=C(OC)C(C4CCCC4)=CC(C5CCCC5)=C3OC

Description

(S,S)-BaryPhos is a chiral bisphosphine ligand featuring a rigid, electron-rich scaffold that enhances enantioselectivity in palladium-catalyzed cross-coupling reactions. This bench-stable, moisture-tolerant ligand integrates seamlessly into asymmetric synthesis workflows, delivering high yield and stereoselectivity across diverse substrates.

Application

(S,S)-BaryPhos serves as a highly effective chiral diphosphine ligand in palladium-catalyzed cross-coupling reactions, enabling efficient asymmetric synthesis of biaryl and allylic compounds. Its robust stereochemical integrity and excellent functional group tolerance facilitate reliable enantioselective transformations under standard reaction conditions. The ligand exhibits superior performance in Suzuki-Miyaura couplings involving aryl halides and pseudohalides, offering high yields and consistent enantiomeric excess. Its bench-stable nature and ease of handling make it well-suited for routine application in medicinal chemistry and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   47.92
  • LogP   8.0811
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   6

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