2-Chloro-4-methyl-6-(trifluoromethyl)pyrimidine

Name: 2-Chloro-4-methyl-6-(trifluoromethyl)pyrimidine
Brand: ChemScene
Availability: InStock
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CAS No. 241164-09-0
Cat. No. CS-0019006
Purity≥96%
MDL No.MFCD08690753

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-4-methyl-6-(trifluoromethyl)pyrimidine|CS-0019006

Structure of 241164-09-0

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General Information

CAS No. 241164-09-0
Cat. No. CS-0019006
Purity ≥96%
MDL No. MFCD08690753
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₄ClF₃N₂
Molecular Weight 196.56
Synonym(s) 2-Chloro-6-methyl-4-(trifluoromethyl)pyrimidine
SMILES FC(C1=CC(C)=NC(Cl)=N1)(F)F

Description

2-Chloro-4-methyl-6-(trifluoromethyl)pyrimidine is a trifluoromethyl-substituted pyrimidine derivative featuring a chloro group at C2 and a methyl substituent at C4. This electron-deficient heterocycle serves as a key building block in medicinal chemistry, enabling efficient access to bioactive molecules through cross-coupling and nucleophilic substitution reactions under standard conditions.

Application

2-Chloro-4-methyl-6-(trifluoromethyl)pyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds via palladium-catalyzed cross-coupling reactions. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the chloro and methyl substituents provide orthogonal reactivity for further functionalization. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for scalable synthesis and API development workflows.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 25.78
LogP 2.45722
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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2-Chloro-4-methyl-6-(trifluoromethyl)pyrimidine

CAS No. 241164-09-0

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