2-Chloro-5-(trifluoromethyl)pyrimidin-4-amine

Name: 2-Chloro-5-(trifluoromethyl)pyrimidin-4-amine
Brand: ChemScene
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CAS No. 24101-09-5
Cat. No. CS-0051962
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-5-(trifluoromethyl)pyrimidin-4-amine|CS-0051962

Structure of 24101-09-5

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General Information

CAS No. 24101-09-5
Cat. No. CS-0051962
Purity ≥98%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₃ClF₃N₃
Molecular Weight 197.55
Synonym(s) None
SMILES NC1=NC(Cl)=NC=C1C(F)(F)F

Description

This trifluoromethyl-substituted pyrimidine amine features a reactive amine handle and electron-deficient heterocyclic core, enabling efficient coupling in cross-coupling and Heterocycle functionalization. The chloro group facilitates nucleophilic substitution under mild conditions, while the trifluoromethyl moiety imparts enhanced metabolic stability and lipophilicity.

Application

2-Chloro-5-(trifluoromethyl)pyrimidin-4-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds. The chloro group facilitates nucleophilic substitution reactions, while the amine functionality offers direct coupling potential. Its stability under standard bench conditions and compatibility with diverse functional groups make it well-suited for modular synthesis of bioactive compounds and API intermediates.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 51.8
LogP 1.731
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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2-Chloro-5-(trifluoromethyl)pyrimidin-4-amine

CAS No. 24101-09-5

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