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CS-W001157 4
Total: USD 88.00

4,7-Dimethoxy-1H-indole

  • CAS No. 23876-39-3

  • Cat. No. CS-0197071
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4,7-Dimethoxy-1H-indole|CS-0197071

Structure of 23876-39-3

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General Information

  • CAS No. 23876-39-3
  • Cat. No. CS-0197071
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₁NO₂
  • Molecular Weight 177.20
  • Synonym(s) 4,7-DIMETHOXYINDOLE
  • SMILES COC1=CC=C(OC)C2=C1NC=C2

Description

4,7-Dimethoxy-1H-indole features two methoxy groups at the 4- and 7-positions of the indole core, enhancing solubility and electronic donation. This electron-rich scaffold serves as a stable building block in synthetic organic chemistry, particularly for pharmaceutical intermediates and functional materials.

Application

4,7-Dimethoxy-1H-indole serves as a valuable building block in medicinal chemistry, enabling direct access to substituted indole scaffolds through standard functional group transformations. Its ortho-dimethoxy substitution pattern enhances solubility and stability while maintaining reactivity in electrophilic aromatic substitution and transition-metal-catalyzed coupling reactions. The molecule functions as a versatile intermediate for the synthesis of heterocyclic compounds and bioactive molecules, offering predictable regioselectivity and ease of purification under routine bench conditions.

Synthesis

  • Route1
    • null|null
      102-71-6
    • In-stock
      2,5-Dimethoxyaniline|CS-W020681
      102-56-7
    • ~15%
    • In-stock
      4,7-Dimethoxy-1H-indole|CS-0197071
      23876-39-3

    References

    • Cho, Chan Sik; Lim, Hyo Kyun; Shim, Sang Chul; Kim, Tae Jeong; Choi, Heung-Jin Chemical Communications, 1998 , # 9 p. 995 - 996
  • Route2
    • null|null
      637-39-8
    • In-stock
      2,5-Dimethoxyaniline|CS-W020681
      102-56-7
    • ~33%
    • In-stock
      4,7-Dimethoxy-1H-indole|CS-0197071
      23876-39-3

    References

    • Cho, Chan Sik; Kim, Jin Hwang; Kim, Tae-Jeong; Shim, Sang Chul Tetrahedron, 2001 , vol. 57, # 16 p. 3321 - 3329
  • Route3

    References

    • Showalter, H. D. Hollis; Pohlmann, Gerd Organic Preparations and Procedures International, 1992 , vol. 24, # 4 p. 484 - 488

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   34.25
  • LogP   2.1851
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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