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CS-W001157 4
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Diethyl (2-(methoxy(methyl)amino)-2-oxoethyl)phosphonate

  • CAS No. 124931-12-0

  • Cat. No. CS-0037993
  • Purity≥96%
  • MDL No.MFCD00134233

*For research and further manufacturing use only, not for direct human use.

Diethyl (2-(methoxy(methyl)amino)-2-oxoethyl)phosphonate|CS-0037993

Structure of 124931-12-0

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General Information

  • CAS No. 124931-12-0
  • Cat. No. CS-0037993
  • Purity ≥96%
  • MDL No. MFCD00134233
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₈NO₅P
  • Molecular Weight 239.21
  • Synonym(s) Diethyl(N-methoxy-N-methylcarbamoylmethyl)phosphonate
  • SMILES CON(C(CP(OCC)(OCC)=O)=O)C

Description

Diethyl (2-(methoxy(methyl)amino)-2-oxoethyl)phosphonate features a phosphonate core paired with a methoxy(methyl)amino carbonyl group, enabling direct integration into peptide mimetics and bioactive heterocycles. The electron-rich nitrogen center enhances reactivity in nucleophilic substitution processes, while the ester functionalities support controlled hydrolysis under physiological conditions. This compound serves as a stable precursor for phosphonate-containing scaffolds in medicinal chemistry.

Synthesis

  • Route1

    References

    • Barthes, Nicolas; Grison, Claude Bioorganic Chemistry, 2012 , vol. 40, # 1 p. 48 - 56
  • Route2
    • null|null
      762-04-9
    • In-stock
      2-Chloro-n-methoxy-n-methylacetamide|CS-W001106
      67442-07-3
    • ~80%
    • In-stock
      Diethyl (2-(methoxy(methyl)amino)-2-oxoethyl)phosphonate|CS-0037993
      124931-12-0

    References

    • Tius, Marcus A.; Busch-Petersen, Jakob Synlett, 1997 , # SPEC. ISS. p. 531 - 533
  • Route3
    • In-stock
      2-Chloro-n-methoxy-n-methylacetamide|CS-W001106
      67442-07-3
    • null|null
      122-52-1
    • ~88%
    • In-stock
      Diethyl (2-(methoxy(methyl)amino)-2-oxoethyl)phosphonate|CS-0037993
      124931-12-0

    References

    • Netz, David F.; Seidel, Jimmy L. Tetrahedron Letters, 1992 , vol. 33, # 15 p. 1957 - 1958

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   65.07
  • LogP   1.2723
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   7

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