Tert-butyl (S)-3-amino-1-oxa-8-azaspiro[4.5]Decane-8-carboxylate

Name: Tert-butyl (S)-3-amino-1-oxa-8-azaspiro[4.5]Decane-8-carboxylate
Brand: ChemScene
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CAS No. 2387567-25-9
Cat. No. CS-0471011
Purity≥98%
MDL No.None

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Tert-butyl (S)-3-amino-1-oxa-8-azaspiro[4.5]Decane-8-carboxylate|CS-0471011

Structure of 2387567-25-9

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General Information

CAS No. 2387567-25-9
Cat. No. CS-0471011
Purity ≥98%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₂₄N₂O₃
Molecular Weight 256.34
Synonym(s) None
SMILES CC(C)(C)OC(=O)N1CCC2(CC1)C[C@H](N)CO2

Description

Tert-butyl (S)-3-amino-1-oxa-8-azaspiro[4.5]decane-8-carboxylate is a stereochemically defined spirocyclic amino ester featuring a constrained 8-azaspiro[4.5]decane core with a bench-stable tert-butyl carbamate protecting group. This scaffold integrates a primary amine and a labile ester moiety, enabling selective functionalization in complex molecule synthesis. The spiro architecture imparts rigidity, enhancing conformational control in target-directed discovery.

Application

Tert-butyl (S)-3-amino-1-oxa-8-azaspiro[4.5]decane-8-carboxylate serves as a versatile chiral building block in medicinal chemistry, enabling efficient access to spirocyclic scaffolds prevalent in bioactive molecules. The protected amine and ester functionalities offer orthogonal reactivity, facilitating downstream derivatization via standard coupling, reduction, or cyclization protocols. Bench-stable and readily purified by chromatography, it functions effectively in multistep synthesis of complex heterocycles and API candidates.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 64.79
LogP 1.5037
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Boc

Building Blocks Functional Group Amine

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aliphatic heterocycle compounds Tetrahydrofuran compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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Tert-butyl (S)-3-amino-1-oxa-8-azaspiro[4.5]Decane-8-carboxylate

CAS No. 2387567-25-9

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