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Structure of 113886-71-8
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N4-Acetyl-2'-O-methylcytidine features a cytidine scaffold with dual modifications: an acetyl group at the N4 position and a methyl ether at the 2' hydroxyl. This combination enhances metabolic stability and resistance to enzymatic degradation. The compound serves as a key building block for synthesizing modified oligonucleotides used in therapeutic and diagnostic applications.
N4-Acetyl-2'-O-methylcytidine serves as a valuable nucleoside building block for the synthesis of modified RNA analogs, particularly in antisense oligonucleotide and siRNA development. Its N4-acetyl and 2'-O-methyl modifications enhance nuclease resistance and binding affinity, while maintaining compatibility with standard phosphoramidite coupling protocols. The compound exhibits excellent bench stability and facilitates efficient solid-phase synthesis, enabling precise incorporation of sterically hindered, bioactive motifs into therapeutic oligonucleotide sequences.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: