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CS-W001157 4
Total: USD 88.00

6-Aminopicolinic acid

  • CAS No. 23628-31-1

  • Cat. No. CS-W002540
  • Purity≥97%
  • MDL No.MFCD00233711

*For research and further manufacturing use only, not for direct human use.

6-Aminopicolinic acid|CS-W002540

Structure of 23628-31-1

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General Information

  • CAS No. 23628-31-1
  • Cat. No. CS-W002540
  • Purity ≥97%
  • MDL No. MFCD00233711
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆N₂O₂
  • Molecular Weight 138.12
  • Synonym(s) None
  • SMILES NC1=CC=CC(C(O)=O)=N1

Description

6-Aminopicolinic acid features a pyridine ring bearing both a carboxylic acid and an amino group at adjacent positions, enabling versatile conjugation and metal coordination. This ortho-substituted structure enhances solubility and reactivity in synthetic transformations. The molecule integrates readily into peptide mimetics and chelating ligands due to its dual functionality and favorable electronic profile.

Application

6-Aminopicolinic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and pharmaceutical intermediates. Its ortho-amino carboxylic acid architecture provides dual functional handles for conjugation, derivatization, and metal chelation. The compound exhibits good bench stability, facilitates straightforward purification via crystallization, and demonstrates compatibility with standard coupling and protection strategies in peptide and small-molecule synthesis.

Synthesis

  • Route1
    • 6-Acetamidopyridine-2-carboxylic acid|CS-0072996
      26893-72-1
    • ~88%
    • In-stock
      6-Aminopicolinic acid|CS-W002540
      23628-31-1

    References

    • Fukase, Koichi; Nakayama, Hideo; Kurosawa, Motohiro; Ikegaki, Toshiki; Kanoh, Takeshi; et al. Journal of Carbohydrate Chemistry, 1994 , vol. 13, # 5 p. 715 - 736
  • Route2

    References

    • Journal of Medicinal Chemistry, , vol. 37, # 14 p. 2238 - 2241
  • Route3

    References

    • Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 11 p. 2741 - 2748

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P264-P270-P280-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   76.21
  • LogP   0.362
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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