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CS-W001157 4
Total: USD 88.00

5-Aminonicotinic acid

  • CAS No. 24242-19-1

  • Cat. No. CS-W002402
  • Purity≥97%
  • MDL No.MFCD00129116

*For research and further manufacturing use only, not for direct human use.

5-Aminonicotinic acid|CS-W002402

Structure of 24242-19-1

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General Information

  • CAS No. 24242-19-1
  • Cat. No. CS-W002402
  • Purity ≥97%
  • MDL No. MFCD00129116
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆N₂O₂
  • Molecular Weight 138.12
  • Synonym(s) 5-Aminopyridine-3-carboxylic Acid
  • SMILES Nc1cc(cnc1)C(=O)O

Description

5-Aminonicotinic acid features a pyridine ring bearing both amino and carboxylic acid functionalities at the 5-position, enabling versatile integration into bioactive molecule scaffolds. This ortho-oriented dual functionality supports efficient conjugation and metal chelation in synthetic and medicinal chemistry applications.

Application

5-Aminonicotinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-amino carboxylic acid functionality offers dual reactivity for coupling, cyclization, and derivatization under standard conditions. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for scalable synthesis workflows.

Synthesis

  • Route1
    • 5-Bromonicotinic acid Nicergoline Impurity|CS-0492508
      20826-04-4
    • ~94%
    • In-stock
      5-Aminonicotinic acid|CS-W002402
      24242-19-1

    References

    • Umezawa, Naoki; Matsumoto, Nobuyoshi; Iwama, Shinsuke; Kato, Nobuki; Higuchi, Tsunehiko Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 17 p. 6340 - 6350
  • Route2

    References

    • Journal of the American Chemical Society, , vol. 70, p. 2381,2383
  • Route3

    References

    • Chemische Berichte, , vol. 61, p. 2211

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   76.21
  • LogP   0.362
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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