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CS-W001157 4
Total: USD 88.00

2-Aminopyrimidine-4-carboxylic acid

  • CAS No. 2164-65-0

  • Cat. No. CS-W021582
  • Purity≥98%
  • MDL No.MFCD07783936

*For research and further manufacturing use only, not for direct human use.

2-Aminopyrimidine-4-carboxylic acid|CS-W021582

Structure of 2164-65-0

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General Information

  • CAS No. 2164-65-0
  • Cat. No. CS-W021582
  • Purity ≥98%
  • MDL No. MFCD07783936
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅N₃O₂
  • Molecular Weight 139.11
  • Synonym(s) 4-pyrimidinecarboxylicacid
  • SMILES O=C(C1=NC(N)=NC=C1)O

Description

2-Aminopyrimidine-4-carboxylic acid features a dual functional group architecture with a nucleophilic amine and an acidic carboxylic acid, enabling versatile conjugation in medicinal chemistry. This scaffold integrates readily into bioactive molecules, particularly within kinase inhibitor frameworks and antiviral agents. The compound exhibits favorable solubility and stability under standard conditions, supporting efficient synthesis and purification workflows.

Application

2-Aminopyrimidine-4-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of pyrimidine-based scaffolds through standard coupling and cyclization reactions. Its dual functionality—amine and carboxylic acid—facilitates modular derivatization, while its inherent stability supports straightforward purification and handling. This compound functions effectively in peptide coupling, amide formation, and heterocycle construction under routine reaction conditions.

Synthesis

  • Route1

    References

    • Yakugaku Zasshi, , vol. 72, p. 913 Chem.Abstr., , p. 6425

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   89.1
  • LogP   -0.243
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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