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CS-W001157 4
Total: USD 88.00

5-Chlorobenzofuran

  • CAS No. 23145-05-3

  • Cat. No. CS-0416281
  • Purity≥97%
  • MDL No.MFCD10699415

*For research and further manufacturing use only, not for direct human use.

5-Chlorobenzofuran|CS-0416281

Structure of 23145-05-3

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General Information

  • CAS No. 23145-05-3
  • Cat. No. CS-0416281
  • Purity ≥97%
  • MDL No. MFCD10699415
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅ClO
  • Molecular Weight 152.58
  • Synonym(s) 5-Chlorobenzo[b]furan
  • SMILES ClC1=CC=C(OC=C2)C2=C1

Description

5-Chlorobenzofuran is a heterocyclic compound featuring a chlorine substituent at the 5-position of the benzofuran core. This electron-deficient scaffold integrates readily into pharmaceutical intermediates and functional materials, offering enhanced metabolic stability and favorable lipophilic character under standard reaction conditions.

Application

5-Chlorobenzofuran serves as a versatile heterocyclic building block in medicinal chemistry and materials science, enabling direct functionalization at the 2- and 3-positions via palladium-catalyzed cross-coupling. Its bench-stable nature and moderate electron-withdrawing character enhance reactivity in Suzuki-Miyaura and Stille transformations, facilitating rapid access to substituted benzofuran scaffolds relevant to API development and organic electronic materials.

Synthesis

  • Route1
    • 1-Chloro-4-(2,2-diethoxyethoxy)benzene|CS-0229836
      41964-04-9
    • ~%
    • In-stock
      5-Chlorobenzofuran|CS-0416281
      23145-05-3

    References

    • WO2004/69829 A1, ; Page 42 ;
  • Route2
    • null|null
      227802-36-0
    • ~74%
    • In-stock
      5-Chlorobenzofuran|CS-0416281
      23145-05-3

    References

    • ELI LILLY AND COMPANY Patent: EP1266897 A2, 2002 ; Location in patent: Page 35 ;
  • Route3
    • null|null
      199010-95-2
    • ~75%
    • In-stock
      5-Chlorobenzofuran|CS-0416281
      23145-05-3

    References

    • Ito, Yasuko; Aoyama, Toyohiko; Shioiri, Takayuki Synlett, 1997 , vol. 1997, # 10 p. 1163 - 1164

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2810
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   13.14
  • LogP   3.0862
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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