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CS-W001157 4
Total: USD 88.00

N-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-iodoquinazolin-4-amine

  • CAS No. 231278-20-9

  • Cat. No. CS-W011494
  • Molecule weight505.71
  • Purity≥97%
  • MDL No.MFCD09998827

*For research and further manufacturing use only, not for direct human use.

N-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-iodoquinazolin-4-amine|CS-W011494

Structure of 231278-20-9

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General Information

  • CAS No. 231278-20-9
  • Cat. No. CS-W011494
  • Purity ≥97%
  • MDL No. MFCD09998827
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₁H₁₄ClFIN₃O
  • Molecular Weight 505.71
  • Synonym(s) None
  • SMILES ClC1=C(OCC2=CC(F)=CC=C2)C=CC(NC3=NC=NC4=C3C=C(I)C=C4)=C1

Description

N-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-iodoquinazolin-4-amine features a quinazoline core with electron-withdrawing halogens at C6 and C3, enhancing reactivity in cross-coupling applications. The para-fluorobenzyl ether linkage provides improved solubility and metabolic stability. This compound serves as a key intermediate in kinase inhibitor synthesis.

Synthesis

  • Route1

    References

    • WO2008/67144 A2, ; Page/Page column 23-24 ;
  • Route2

    References

    • EP1481971 A1, ; Page 8-9 ;
  • Route3
    • null|null
      1227853-05-5
    • In-stock
      2-Amino-5-iodobenzonitrile|CS-0130296
      132131-24-9
    • ~%
    • In-stock
      N-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-iodoquinazolin-4-amine|CS-W011494
      231278-20-9

    References

    • WO2010/61400 A1, ; Page/Page column 14-15 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   47.04
  • LogP   6.3495
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   5

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