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CS-W001157 4
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2-(2-(tert-Butoxycarbonyl)-2-azaspiro[3.5]nonan-7-yl)acetic acid

  • CAS No. 2306261-01-6

  • Cat. No. CS-0623560
  • Purity≥98%
  • MDL No.MFCD31744309

*For research and further manufacturing use only, not for direct human use.

2-(2-(tert-Butoxycarbonyl)-2-azaspiro[3.5]nonan-7-yl)acetic acid|CS-0623560

Structure of 2306261-01-6

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General Information

  • CAS No. 2306261-01-6
  • Cat. No. CS-0623560
  • Purity ≥98%
  • MDL No. MFCD31744309
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₂₅NO₄
  • Molecular Weight 283.37
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)N1CC2(C1)CCC(CC(=O)O)CC2

Description

This spirocyclic amino acid derivative features a protected tertiary amine within a rigid 3.5-spirocycle framework, enabling controlled incorporation into peptide-based scaffolds. The tert-butoxycarbonyl group provides orthogonal protection for nitrogen functionalization, while the acetic acid side chain offers a handle for conjugation or further derivatization under standard coupling conditions.

Application

2-(2-(tert-Butoxycarbonyl)-2-azaspiro[3.5]nonan-7-yl)acetic acid serves as a versatile spirocyclic building block for medicinal chemistry and peptide synthesis, enabling the incorporation of constrained azaspiro[3.5]nonane motifs into bioactive molecules. The tert-butyl carbamate group provides excellent stability and orthogonal protection, facilitating selective deprotection during downstream functionalization. Its acetic acid side chain allows for conjugation via amide or ester linkages, supporting applications in scaffold diversification and target-oriented synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   2.8884
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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