tert-Butyl 7-hydroxy-2-azaspiro[3.5]nonane-2-carboxylate

Name: tert-Butyl 7-hydroxy-2-azaspiro[3.5]nonane-2-carboxylate
Brand: ChemScene
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CAS No. 1363383-18-9
Cat. No. CS-0042478
Purity≥95%
MDL No.MFCD20926146

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FedEx Limited Quantities Ground	$0.00
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tert-Butyl 7-hydroxy-2-azaspiro[3.5]nonane-2-carboxylate|CS-0042478

Structure of 1363383-18-9

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General Information

CAS No. 1363383-18-9
Cat. No. CS-0042478
Purity ≥95%
MDL No. MFCD20926146
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₂₃NO₃
Molecular Weight 241.33
Synonym(s) 7-Hydroxy-2-azaspiro[3.5]nonane-2-carboxylic acid 1,1-dimethylethyl ester
SMILES O=C(N1CC2(CCC(O)CC2)C1)OC(C)(C)C

Description

tert-Butyl 7-hydroxy-2-azaspiro[3.5]nonane-2-carboxylate features a rigid spirocyclic scaffold with a pendant hydroxyl group and a bench-stable tert-butyl carbamate. This configuration enables direct functionalization at the C7 position while maintaining structural integrity under standard reaction conditions. The molecule serves as a key intermediate in the synthesis of complex nitrogen-containing polycycles, particularly in medicinal chemistry campaigns targeting bioactive alkaloid analogs.

Application

tert-Butyl 7-hydroxy-2-azaspiro[3.5]nonane-2-carboxylate serves as a versatile spirocyclic scaffold for medicinal chemistry applications, enabling efficient access to complex nitrogen-containing heterocycles. The pendant hydroxyl group offers direct handle for derivatization via esterification, etherification, or oxidation, while the tert-butyl carbamate protects the amine under standard synthetic conditions. Its stability, ease of purification, and compatibility with diverse coupling reactions make it a practical building block for target-oriented synthesis.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

TPSA 49.77
LogP 2.1584
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Boc

Building Blocks Functional Group Alcohol

Building Blocks Skeleton Aliphatic heterocycle compounds Azetidine compounds

Key Words

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tert-Butyl 7-hydroxy-2-azaspiro[3.5]nonane-2-carboxylate

CAS No. 1363383-18-9

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