E3 ligase Ligand 63

Name: E3 ligase Ligand 63
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 2304754-51-4
Cat. No. CS-0158732
Purity≥98%
MDL No.MFCD34183045

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

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Description

E3 ligase Ligand 63 is a potent, cell-permeable modulator designed to engage specific E3 ubiquitin ligases for targeted protein degradation. This small molecule features a unique scaffold that enables selective recruitment of the ligase complex, facilitating efficient ubiquitination and proteasomal processing of disease-relevant targets. Its stability under physiological conditions supports reliable use in cellular assays and target validation workflows.

Application

E3 ligase Ligand 63 serves as a well-characterized molecular scaffold for targeted protein degradation, enabling efficient recruitment of E3 ubiquitin ligases in PROTAC®-based strategies. Its defined functional groups support orthogonal conjugation and demonstrate robust stability under physiological conditions, facilitating reliable synthesis and purification. This compound functions as a key warhead component in bifunctional degraders, offering high selectivity and compatibility with standard medicinal chemistry workflows.

General Information

CAS No. 2304754-51-4
Cat. No. CS-0158732
Purity ≥98%
MDL No. MFCD34183045
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₁₂BrN₃O₃
Molecular Weight 338.16
Synonym(s) None
SMILES O=C(C(N1C2=CC=CC(Br)=C2N(C)C1=O)CC3)NC3=O

Computational Chemistry Data

TPSA 73.1
LogP 1.0802
H_Acceptors 5
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319
Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Benzimidazole compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Life Science PROTAC Ligands for E3 Ligase

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

Key Words

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E3 ligase Ligand 63

CAS No. 2304754-51-4

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