E3 ligase Ligand 32

Name: E3 ligase Ligand 32
Brand: ChemScene
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CAS No. 2300099-98-1
Cat. No. CS-0492657
Purity≥96%
MDL No.MFCD34595287

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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General Information

CAS No. 2300099-98-1
Cat. No. CS-0492657
Purity ≥96%
MDL No. MFCD34595287
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₁₂BrN₃O₃
Molecular Weight 338.16
Synonym(s) 3-(5-Bromo-3-Methyl-2-Oxo-2,3-Dihydro-1H-Benzo[D]Imidazol-1-Yl)Piperidine-2,6-Dione
SMILES O=C1NC(=O)C(CC1)N2C3=C(C=C(Br)C=C3)N(C)C2=O

Description

E3 ligase Ligand 32 features a sterically hindered core that enables selective engagement with target E3 ubiquitin ligases, facilitating efficient protein degradation. This ligand integrates robust stability under physiological conditions and demonstrates favorable binding kinetics, supporting its use in targeted proteolysis applications.

Application

E3 ligase Ligand 32 serves as a well-characterized molecular scaffold for targeted protein degradation, enabling selective ubiquitination of disease-relevant targets. It functions as a high-affinity binder to E3 ubiquitin ligases, facilitating efficient recruitment of substrate proteins in PROTAC-based systems. Its stability and compatibility with common coupling chemistries make it a practical building block for developing degrader molecules in medicinal chemistry workflows.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319
Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P501

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Computational Chemistry Data

TPSA 73.1
LogP 1.0802
H_Acceptors 5
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Benzimidazole compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Life Science PROTAC Ligands for E3 Ligase

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

Key Words

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E3 ligase Ligand 32

CAS No. 2300099-98-1

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