Lot numbers can be found on the outside label of a product:
(R)-4-Hydroxypyrrolidin-2-one
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CAS No. 22677-21-0
- Cat. No. CS-W013709
- Purity≥97%
- MDL No.MFCD00273364
*For research and further manufacturing use only, not for direct human use.
Structure of 22677-21-0
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General Information
- CAS No. 22677-21-0
- Cat. No. CS-W013709
- Purity ≥97%
- MDL No. MFCD00273364
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₄H₇NO₂
- Molecular Weight 101.10
- Synonym(s) (R)-(+)-4-Hydroxy-2-pyrrolidone
- SMILES O=C1NC[C@H](O)C1
Description
(R)-4-Hydroxypyrrolidin-2-one is a stereochemically defined heterocyclic scaffold featuring a hydroxyl group at the C4 position and a lactam functionality. This configuration imparts enhanced solubility and metabolic stability, enabling its use in asymmetric synthesis and as a chiral building block for bioactive molecules.
Application
(R)-4-Hydroxypyrrolidin-2-one serves as a versatile chiral building block in medicinal chemistry, enabling efficient access to pyrrolidine-based pharmacophores. Its hydroxyl group provides a handle for selective derivatization, while the lactam functionality offers inherent stability and favorable solubility. The stereochemistry at C4 ensures predictable stereoselective transformations, facilitating its use in asymmetric synthesis and API development.
Synthesis
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Route1
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208103-39-3 - ~%
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In-stock
22677-21-0
References
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US6031113 A1, ;
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Route2
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135056-42-7 - ~51%
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In-stock
22677-21-0
References
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Aube; Wang; Ghosh; Langhans Synthetic Communications, 1991 , vol. 21, # 5 p. 693 - 701
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Route3
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131653-48-0 - ~%
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In-stock
22677-21-0
References
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Journal of Chemical Research, Miniprint, , # 11 p. 2701 - 2711
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 49.33
- LogP -1.1328
- H_Acceptors 2
- H_Donors 2
- Rotatable_Bonds 0
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Key Words
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