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CS-W001157 4
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7-Chloro-1,3-dioxaindane-5-carboxylic acid

  • CAS No. 22519-35-3

  • Cat. No. CS-0225097
  • Purity≥97%
  • MDL No.None
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

7-Chloro-1,3-dioxaindane-5-carboxylic acid|CS-0225097

Structure of 22519-35-3

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Description

7-Chloro-1,3-dioxaindane-5-carboxylic acid features a rigid, electron-deficient dioxaindane core that enhances metabolic stability and facilitates efficient coupling in synthetic transformations. This bench-stable scaffold integrates readily into complex molecular architectures, offering predictable reactivity under standard conditions.

Application

7-Chloro-1,3-dioxaindane-5-carboxylic acid serves as a versatile building block for heterocyclic synthesis, particularly in the construction of biologically relevant indoline and indole scaffolds. The molecule combines a stable dioxane-fused indane core with a carboxylic acid functionality that enables direct coupling reactions or derivatization. Its chlorine substituent provides a handle for further functionalization via nucleophilic substitution or transition-metal-catalyzed processes. The compound exhibits good bench stability and facilitates straightforward purification, making it suitable for iterative synthetic campaigns in medicinal chemistry and process development.

General Information

  • CAS No. 22519-35-3
  • Cat. No. CS-0225097
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅ClO₄
  • Molecular Weight 200.58
  • Synonym(s) None
  • SMILES O=C(C1=CC2=C(OCO2)C(Cl)=C1)O

Computational Chemistry Data

  • TPSA   55.76
  • LogP   1.7669
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram : N/A
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UN#: N/A
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Hazard Statements : N/A
Precautionary Statements : N/A

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