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CS-W001157 4
Total: USD 88.00

4-Amino-3-fluoropyridine

  • CAS No. 2247-88-3

  • Cat. No. CS-W007902
  • Purity≥98%
  • MDL No.MFCD00234072

*For research and further manufacturing use only, not for direct human use.

4-Amino-3-fluoropyridine|CS-W007902

Structure of 2247-88-3

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General Information

  • CAS No. 2247-88-3
  • Cat. No. CS-W007902
  • Purity ≥98%
  • MDL No. MFCD00234072
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅FN₂
  • Molecular Weight 112.11
  • Synonym(s) fluoropyridin-4-amine
  • SMILES NC1=C(C=NC=C1)F

Application

4-Amino-3-fluoropyridine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the 3-position via nucleophilic substitution due to the fluorine's high reactivity. Its amino group facilitates coupling reactions and hydrogen bonding interactions in target molecules. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for iterative synthesis of heterocyclic scaffolds and API intermediates.

Synthesis

  • Route1
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      769-54-0
    • ~%
    • In-stock
      4-Amino-3-fluoropyridine|CS-W007902
      2247-88-3

    References

    • Journal fuer Praktische Chemie (Leipzig), , vol. 330, # 1 p. 154 - 158
  • Route2
    • null|null
      695-37-4
    • ~%
    • In-stock
      4-Amino-3-fluoropyridine|CS-W007902
      2247-88-3

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 6, # 3 p. 333 - 338

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P264-P270-P280-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   0.8029
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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