2,5-Difluoropyridin-4-amine

Name: 2,5-Difluoropyridin-4-amine
Brand: ChemScene
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CAS No. 189281-61-6
Cat. No. CS-0157804
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 189281-61-6
Cat. No. CS-0157804
Purity ≥98%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₄F₂N₂
Molecular Weight 130.10
Synonym(s) 4-Pyridinamine,2,5-difluoro-(9CI)
SMILES C1=C(C(=CN=C1F)F)N

Description

2,5-Difluoropyridin-4-amine features a fluorinated pyridine core with strategically positioned electron-withdrawing substituents. This configuration enhances electrophilicity at the 4-position, enabling efficient coupling reactions in C–H functionalization and transition-metal-catalyzed transformations. The molecule exhibits bench-stable handling characteristics and compatibility with diverse reaction conditions.

Application

2,5-Difluoropyridin-4-amine serves as a versatile building block in medicinal chemistry, enabling direct functionalization via nucleophilic aromatic substitution due to the activating effect of the amine and the electron-withdrawing fluorine substituents. Its bench-stable nature and compatibility with standard coupling reactions facilitate efficient synthesis of fluorinated heterocyclic scaffolds relevant to pharmaceutical development.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 38.91
LogP 0.942
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2,5-Difluoropyridin-4-amine

CAS No. 189281-61-6

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