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Structure of 22364-68-7
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2-(o-Tolyl)acetonitrile features a benzene ring substituted with both a methyl group and a nitrile-bearing acetyl side chain, delivering a sterically constrained, electron-deficient aryl moiety. This configuration enables efficient coupling in transition metal-catalyzed reactions and serves as a robust building block for heterocyclic synthesis under standard conditions.
2-(o-Tolyl)acetonitrile serves as a versatile building block in synthetic organic chemistry, enabling efficient construction of heterocyclic scaffolds and functionalized aryl derivatives. Its ortho-tolyl group provides steric and electronic modulation, while the nitrile functionality facilitates nucleophilic addition, cyclization, and transition-metal-catalyzed transformations. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for use in medicinal chemistry campaigns and process development workflows.
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GHS No : GHS06
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Signal Word : Danger
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UN#: 3276
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H302+H312-H315-H319-H331-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: