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CS-W001157 4
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1-Benzylazetidin-3-amine

  • CAS No. 223381-58-6

  • Cat. No. CS-0052597
  • Molecule weight162.23
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-Benzylazetidin-3-amine|CS-0052597

Structure of 223381-58-6

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General Information

  • CAS No. 223381-58-6
  • Cat. No. CS-0052597
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₄N₂
  • Molecular Weight 162.23
  • Synonym(s) 3-Azetidinamine, 1-(phenylmethyl)-
  • SMILES NC1CN(CC2=CC=CC=C2)C1

Description

1-Benzylazetidin-3-amine features a bicyclic azetidine core fused with a benzylated amine side chain, delivering enhanced metabolic stability and improved membrane permeability. This scaffold integrates a primary amine at the 3-position with a benzylic handle, enabling direct conjugation or functionalization in bioconjugate chemistry and medicinal discovery.

Application

1-Benzylazetidin-3-amine serves as a versatile building block for medicinal chemistry, enabling the construction of azetidine-based scaffolds prevalent in bioactive molecules. Its benzyl group enhances solubility and stability, while the primary amine facilitates straightforward functionalization via alkylation, acylation, or reductive amination. The molecule exhibits excellent bench stability and compatibility with standard purification methods, making it ideal for iterative synthesis workflows in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.26
  • LogP   0.8295
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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