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Benzyl azetidin-3-ylcarbamate hydrochloride

  • CAS No. 1203099-07-3

  • Cat. No. CS-0045529
  • Purity≥97%
  • MDL No.MFCD11101353

*For research and further manufacturing use only, not for direct human use.

Benzyl azetidin-3-ylcarbamate hydrochloride|CS-0045529

Structure of 1203099-07-3

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General Information

  • CAS No. 1203099-07-3
  • Cat. No. CS-0045529
  • Purity ≥97%
  • MDL No. MFCD11101353
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₅ClN₂O₂
  • Molecular Weight 242.70
  • Synonym(s) 3-(CBZ-AMINO)AZETIDINE-HCL
  • SMILES O=C(OCC1=CC=CC=C1)NC2CNC2.[H]Cl

Description

Benzyl azetidin-3-ylcarbamate hydrochloride features a sterically constrained azetidine core linked to a benzyl-protected carbamate, enabling direct incorporation into peptide-like scaffolds. This bench-stable derivative delivers enhanced solubility and compatibility in synthetic workflows involving nitrogen heterocycles.

Application

Benzyl azetidin-3-ylcarbamate hydrochloride serves as a robust, bench-stable building block for the synthesis of bioactive azetidine-containing molecules. The carbamate functionality enables orthogonal protection of the amine, while the benzyl group facilitates straightforward deprotection under mild hydrogenolysis conditions. This compound exhibits excellent functional group tolerance and reactivity in standard coupling protocols, making it particularly valuable for constructing diverse heterocyclic scaffolds in medicinal chemistry and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.36
  • LogP   1.3064
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   3

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