tert-Butyl 3-(methylamino)azetidine-1-carboxylate

Name: tert-Butyl 3-(methylamino)azetidine-1-carboxylate
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CAS No. 454703-20-9
Cat. No. CS-W005439
Purity≥97%
MDL No.MFCD08061962

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tert-Butyl 3-(methylamino)azetidine-1-carboxylate|CS-W005439

Structure of 454703-20-9

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General Information

CAS No. 454703-20-9
Cat. No. CS-W005439
Purity ≥97%
MDL No. MFCD08061962
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₁₈N₂O₂
Molecular Weight 186.25
Synonym(s) 1-tert-Butoxycarbonyl-3-(methylamino)azetidine
SMILES O=C(N1CC(NC)C1)OC(C)(C)C

Description

tert-Butyl 3-(methylamino)azetidine-1-carboxylate is a bench-stable, moisture-tolerant azetidine building block featuring a methylamino substituent that enhances nucleophilicity and solubility. This protected amine integrates efficiently into diverse synthetic sequences, enabling streamlined access to bioactive heterocycles in medicinal chemistry and peptide conjugation workflows.

Application

tert-Butyl 3-(methylamino)azetidine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient access to azetidine-containing scaffolds. The tert-butyl carbamate group provides excellent bench stability and facile removal under mild acidic conditions, while the methylamino functionality offers direct handle for further functionalization. It reacts predictably in standard coupling, reductive amination, and cyclization protocols, making it ideal for constructing bioactive heterocycles in API development workflows.

Safety Information

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GHS Pictogram :	GHS No : GHS06
Signal Word : Danger	UN#: 2811
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

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Computational Chemistry Data

TPSA 41.57
LogP 0.8251
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Skeleton Aliphatic heterocycle compounds Azetidine compounds

Key Words

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tert-Butyl 3-(methylamino)azetidine-1-carboxylate

CAS No. 454703-20-9

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