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CS-W001157 4
Total: USD 88.00

Hydroxy-PEG4-C2-methyl ester

  • CAS No. 2228857-35-8

  • Cat. No. CS-0114951
  • Purity≥97%
  • MDL No.MFCD31654023

*For research and further manufacturing use only, not for direct human use.

Hydroxy-PEG4-C2-methyl ester|CS-0114951

Structure of 2228857-35-8

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General Information

  • CAS No. 2228857-35-8
  • Cat. No. CS-0114951
  • Purity ≥97%
  • MDL No. MFCD31654023
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₄O₇
  • Molecular Weight 280.31
  • Synonym(s) None
  • SMILES O=C(OC)CCOCCOCCOCCOCCO

Description

Hydroxy-PEG4-C2-methyl ester features a hydroxyl-terminated polyethylene glycol chain of four ethylene oxide units, linked via a C2 spacer to a methyl ester group. This amphiphilic construct offers enhanced solubility in aqueous and organic media, enabling seamless integration into conjugation workflows. The terminal hydroxyl supports further derivatization, while the stable ester linkage resists premature hydrolysis under standard conditions.

Application

Hydroxy-PEG4-C2-methyl ester serves as a versatile bifunctional building block for conjugation and solubilization in synthetic chemistry. The terminal hydroxyl group enables further derivatization, while the C2 methyl ester functions as a stable, easily cleavable linker under mild basic conditions. Its PEG4 spacer provides enhanced aqueous solubility and reduced aggregation, making it ideal for peptide, oligonucleotide, and small-molecule conjugates requiring improved pharmacokinetic profiles and compatibility with standard synthetic workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   83.45
  • LogP   -0.3918
  • H_Acceptors   7
  • H_Donors   1
  • Rotatable_Bonds   14

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