Bicyclo[1.1.1]pentan-1-amine hydrochloride

Name: Bicyclo[1.1.1]pentan-1-amine hydrochloride
Brand: ChemScene
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CAS No. 22287-35-0
Cat. No. CS-W000429
Purity≥96%
MDL No.MFCD19204065

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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Bicyclo[1.1.1]pentan-1-amine hydrochloride|CS-W000429

Structure of 22287-35-0

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General Information

CAS No. 22287-35-0
Cat. No. CS-W000429
Purity ≥96%
MDL No. MFCD19204065
Storage Store at room temperature, keep dry and cool
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₁₀ClN
Molecular Weight 119.59
Synonym(s) Propellamine HCl
SMILES NC1(C2)CC2C1.Cl

Description

Bicyclo[1.1.1]pentan-1-amine hydrochloride features a rigid, strain-engineered cage framework that imparts exceptional thermal and metabolic stability. This bench-stable derivative serves as a privileged scaffold in medicinal chemistry, enabling efficient incorporation of nitrogen functionality into bioactive molecules with enhanced membrane permeability and target engagement.

Application

Bicyclo[1.1.1]pentan-1-amine hydrochloride serves as a rigid, conformationally constrained amine building block for medicinal chemistry and catalysis. Its stable, sterically encumbered scaffold enables precise spatial positioning of functional groups, enhancing target binding affinity in drug discovery. The hydrochloride salt improves solubility and handling, facilitating purification and incorporation into diverse synthetic sequences including amide couplings and reductive aminations.

Synthesis

Route1
- 136863-38-2
- ~16%
- In-stock
  
  22287-35-0
References
- Bunker, Kevin D.; Sach, Neal W.; Huang, Qinhua; Richardson, Paul F. Organic Letters, 2011 , vol. 13, # 17 p. 4746 - 4748

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 26.02
LogP 0.9194
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Bridge Rings compounds Other bridge ring compounds

Building Blocks Skeleton Fatty ring compounds Cyclobutane compounds

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Specialized Building Blocks for Drug Discovery Bicyclo[1.1.1]pentane Building Blocks

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Bicyclo[1.1.1]pentan-1-amine hydrochloride

CAS No. 22287-35-0

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