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CS-W001157 4
Total: USD 88.00

Pomalidomide-C2-acid

  • CAS No. 2225940-46-3

  • Cat. No. CS-0534254
  • Purity≥96%
  • MDL No.MFCD32898771

*For research and further manufacturing use only, not for direct human use.

Pomalidomide-C2-acid|CS-0534254

Structure of 2225940-46-3

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General Information

  • CAS No. 2225940-46-3
  • Cat. No. CS-0534254
  • Purity ≥96%
  • MDL No. MFCD32898771
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₁₅N₃O₆
  • Molecular Weight 345.31
  • Synonym(s) None
  • SMILES O=C(CCNC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O)O

Description

Pomalidomide-C2-acid features a C2-carboxylic acid functionalization that enhances solubility and reactivity for conjugation workflows. This derivative enables site-specific bioconjugation in targeted protein therapeutics, offering improved stability and compatibility with aqueous reaction conditions.

Application

Pomalidomide-C2-acid serves as a key synthetic intermediate for derivatization of the imidazolone core in pomalidomide-based therapeutics. Its C2-carboxylic acid functionality enables direct amidation, esterification, or coupling reactions under standard peptide synthesis conditions, facilitating rapid access to analogs for structure-activity studies. The compound exhibits good bench stability and is compatible with common purification methods, supporting efficient route development in medicinal chemistry campaigns targeting immunomodulatory agents.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS08
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H361
Precautionary Statements : P280-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   132.88
  • LogP   -0.6592
  • H_Acceptors   9
  • H_Donors   3
  • Rotatable_Bonds   5

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