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6-(Trifluoromethyl)picolinamide

  • CAS No. 22245-84-7

  • Cat. No. CS-0136720
  • Molecule weight190.12
  • Purity≥98%
  • MDL No.MFCD02180820

*For research and further manufacturing use only, not for direct human use.

6-(Trifluoromethyl)picolinamide|CS-0136720

Structure of 22245-84-7

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General Information

  • CAS No. 22245-84-7
  • Cat. No. CS-0136720
  • Purity ≥98%
  • MDL No. MFCD02180820
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅F₃N₂O
  • Molecular Weight 190.12
  • Synonym(s) 6-(Trifluoromethyl)pyridine-2-carboxamide
  • SMILES O=C(C1=NC(C(F)(F)F)=CC=C1)N

Description

6-(Trifluoromethyl)picolinamide delivers a potent electron-withdrawing trifluoromethyl group positioned para to the amide functionality, enhancing both metabolic stability and binding affinity in medicinal chemistry applications. This bench-stable, moisture-tolerant heterocycle integrates seamlessly into drug discovery campaigns requiring strong dipole moments and improved membrane permeability.

Application

6-(Trifluoromethyl)picolinamide serves as a versatile building block in medicinal chemistry, enabling direct incorporation of a trifluoromethyl group at the C6 position of the picolinamide scaffold. Its stability under standard reaction conditions and compatibility with common coupling protocols facilitate efficient derivatization. The molecule functions as a key intermediate for constructing bioactive heterocycles, particularly in the development of kinase inhibitors and CNS-targeted therapeutics, owing to its enhanced metabolic stability and lipophilic character.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   55.98
  • LogP   1.1993
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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