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CS-W001157 4
Total: USD 88.00

6-(Trifluoromethyl)picolinonitrile

  • CAS No. 887583-52-0

  • Cat. No. CS-0101108
  • Molecule weight172.11
  • Purity≥98%
  • MDL No.MFCD07368048

*For research and further manufacturing use only, not for direct human use.

6-(Trifluoromethyl)picolinonitrile|CS-0101108

Structure of 887583-52-0

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General Information

  • CAS No. 887583-52-0
  • Cat. No. CS-0101108
  • Purity ≥98%
  • MDL No. MFCD07368048
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₃F₃N₂
  • Molecular Weight 172.11
  • Synonym(s) 6-(Trifluoromethyl)pyridine-2-carbonitrile
  • SMILES N#CC1=NC(C(F)(F)F)=CC=C1

Description

6-(Trifluoromethyl)picolinonitrile features a trifluoromethyl group at the 6-position of the picolinonitrile scaffold, imparting enhanced electron-withdrawing character and metabolic stability. This configuration enables efficient incorporation into heterocyclic scaffolds for pharmaceutical intermediates and agrochemicals. The molecule exhibits robust bench stability and favorable solubility in common organic solvents, facilitating use in multistep synthesis workflows.

Application

6-(Trifluoromethyl)picolinonitrile serves as a versatile building block in medicinal chemistry and materials science, enabling the synthesis of heterocyclic scaffolds through nucleophilic addition and cyclization reactions. Its dual electron-withdrawing trifluoromethyl and nitrile groups enhance reactivity in transition-metal-catalyzed couplings and facilitate functional group interconversions. The compound exhibits good bench stability and is compatible with standard purification protocols, making it well-suited for scalable synthesis and downstream derivatization.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   36.68
  • LogP   1.97208
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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