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Structure of 887583-52-0
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6-(Trifluoromethyl)picolinonitrile features a trifluoromethyl group at the 6-position of the picolinonitrile scaffold, imparting enhanced electron-withdrawing character and metabolic stability. This configuration enables efficient incorporation into heterocyclic scaffolds for pharmaceutical intermediates and agrochemicals. The molecule exhibits robust bench stability and favorable solubility in common organic solvents, facilitating use in multistep synthesis workflows.
6-(Trifluoromethyl)picolinonitrile serves as a versatile building block in medicinal chemistry and materials science, enabling the synthesis of heterocyclic scaffolds through nucleophilic addition and cyclization reactions. Its dual electron-withdrawing trifluoromethyl and nitrile groups enhance reactivity in transition-metal-catalyzed couplings and facilitate functional group interconversions. The compound exhibits good bench stability and is compatible with standard purification protocols, making it well-suited for scalable synthesis and downstream derivatization.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: