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Structure of 22245-84-7
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6-(Trifluoromethyl)picolinamide delivers a potent electron-withdrawing trifluoromethyl group positioned para to the amide functionality, enhancing both metabolic stability and binding affinity in medicinal chemistry applications. This bench-stable, moisture-tolerant heterocycle integrates seamlessly into drug discovery campaigns requiring strong dipole moments and improved membrane permeability.
6-(Trifluoromethyl)picolinamide serves as a versatile building block in medicinal chemistry, enabling direct incorporation of a trifluoromethyl group at the C6 position of the picolinamide scaffold. Its stability under standard reaction conditions and compatibility with common coupling protocols facilitate efficient derivatization. The molecule functions as a key intermediate for constructing bioactive heterocycles, particularly in the development of kinase inhibitors and CNS-targeted therapeutics, owing to its enhanced metabolic stability and lipophilic character.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: