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CS-W001157 4
Total: USD 88.00

Bavdegalutamide

  • CAS No. 2222112-77-6

  • Cat. No. CS-0159884
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Bavdegalutamide|CS-0159884

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General Information

  • CAS No. 2222112-77-6
  • Cat. No. CS-0159884
  • Purity ≥98%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄₁H₄₃ClFN₉O₆
  • Molecular Weight 812.29
  • Synonym(s) ARV-110
  • SMILES O=C(C1=NN=C(N2CCC(CN3CCN(C4=CC5=C(C(N(C(CC6)C(NC6=O)=O)C5=O)=O)C=C4F)CC3)CC2)C=C1)N[C@H]7CC[C@H](OC8=CC=C(C#N)C(Cl)=C8)CC7

Description

Bavdegalutamide is a potent, selective, and orally bioavailable inhibitor of the E3 ubiquitin ligase cereblon. This molecule integrates a degron-recognition motif that enables targeted protein degradation via the ubiquitin-proteasome system. Its optimized structure enhances cellular permeability and metabolic stability, facilitating effective modulation of disease-relevant targets in preclinical models.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   181.17
  • LogP   3.70058
  • H_Acceptors   12
  • H_Donors   2
  • Rotatable_Bonds   9

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