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CS-W001157 4
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(S)-4-(tert-Butyl)-2-(quinolin-8-yl)-4,5-dihydrooxazole

  • CAS No. 220629-00-5

  • Cat. No. CS-0610832
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(S)-4-(tert-Butyl)-2-(quinolin-8-yl)-4,5-dihydrooxazole|CS-0610832

Structure of 220629-00-5

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General Information

  • CAS No. 220629-00-5
  • Cat. No. CS-0610832
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₁₈N₂O
  • Molecular Weight 254.33
  • Synonym(s) None
  • SMILES CC([C@@H]1N=C(C2=C3N=CC=CC3=CC=C2)OC1)(C)C

Description

This chiral oxazole features a sterically hindered tert-butyl group and a quinolin-8-yl moiety, delivering enhanced stability and defined stereochemistry. It integrates readily into complex molecular architectures, particularly in medicinal chemistry scaffolds requiring rigid, electron-deficient heterocycles for target engagement.

Application

(S)-4-(tert-Butyl)-2-(quinolin-8-yl)-4,5-dihydrooxazole serves as a versatile chiral building block for the synthesis of bioactive heterocycles. Its dihydrooxazole core exhibits robust bench stability and compatibility with standard functional group transformations. The tert-butyl group enhances solubility and facilitates purification, while the quinolin-8-yl moiety provides a rigid, planar scaffold useful in medicinal chemistry campaigns targeting kinase inhibitors and CNS-active compounds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   34.48
  • LogP   3.4263
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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