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CS-W001157 4
Total: USD 88.00

3',4',5'-Trifluoroacetophenone

  • CAS No. 220141-73-1

  • Cat. No. CS-W017525
  • Purity≥98%
  • MDL No.MFCD00083533

*For research and further manufacturing use only, not for direct human use.

3',4',5'-Trifluoroacetophenone|CS-W017525

Structure of 220141-73-1

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General Information

  • CAS No. 220141-73-1
  • Cat. No. CS-W017525
  • Purity ≥98%
  • MDL No. MFCD00083533
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅F₃O
  • Molecular Weight None
  • Synonym(s) 1-(3,4,5-Trifluorophenyl)ethanone
  • SMILES C1=C(C=C(F)C(=C1F)F)C(C)=O

Description

3',4',5'-Trifluoroacetophenone features a trifluoromethyl-substituted aromatic ring paired with a reactive ketone group, enabling direct incorporation into cross-coupling and electrophilic functionalization sequences. The electron-deficient aryl system enhances reactivity in transition metal-catalyzed transformations, while the bench-stable ketone facilitates reliable handling under standard conditions.

Application

3',4',5'-Trifluoroacetophenone serves as a valuable building block in medicinal chemistry and agrochemical synthesis, offering enhanced metabolic stability and modulated lipophilicity due to its trifluoromethyl-substituted aromatic ring. The ketone functionality enables straightforward transformations including nucleophilic additions, reductions, and condensation reactions, facilitating access to complex heterocyclic scaffolds. Its bench-stable nature and compatibility with common synthetic protocols make it a practical choice for multi-step sequences.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.3065
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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