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CS-W001157 4
Total: USD 88.00

1-(3,4-Difluorophenyl)ethanone

  • CAS No. 369-33-5

  • Cat. No. CS-W016243
  • Purity≥98%
  • MDL No.MFCD00009891

*For research and further manufacturing use only, not for direct human use.

1-(3,4-Difluorophenyl)ethanone|CS-W016243

Structure of 369-33-5

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General Information

  • CAS No. 369-33-5
  • Cat. No. CS-W016243
  • Purity ≥98%
  • MDL No. MFCD00009891
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆F₂O
  • Molecular Weight 156.13
  • Synonym(s) 3',4'-Difluoroacetophenone
  • SMILES CC(C1=CC=C(F)C(F)=C1)=O

Description

3,4-Difluoroacetophenone may be used in chemical synthesis.

Application

1-(3,4-Difluorophenyl)ethanone serves as a versatile aryl ketone building block in medicinal chemistry and synthetic organic research. Its difluorinated aromatic ring enhances metabolic stability and modulates lipophilicity, while the acetyl group enables standard transformations such as nucleophilic additions, reductions, and coupling reactions. The compound exhibits excellent bench stability and is readily purified by crystallization or column chromatography, facilitating its use in multi-step syntheses of pharmaceutical intermediates and functionalized heterocycles.

Synthesis

  • Route1
    • null|null
      367-11-3
    • null|null
      75-36-5
    • ~80%
    • In-stock
      1-(3,4-Difluorophenyl)ethanone|CS-W016243
      369-33-5

    References

    • Joshi, Krishna C.; Pathak, Vijai N.; Grover, Vineeta Journal of Fluorine Chemistry, 1980 , vol. 15, p. 245 - 252
  • Route2
    • null|null
      76903-88-3
    • ~%
    • In-stock
      1-(3,4-Difluorophenyl)ethanone|CS-W016243
      369-33-5

    References

    • Piotrowski, David W. Synlett, 1999 , # 7 p. 1091 - 1093
  • Route3
    • null|null
      367-11-3
    • null|null
      108-24-7
    • ~%
    • In-stock
      1-(3,4-Difluorophenyl)ethanone|CS-W016243
      369-33-5

    References

    • Minor; Vanderwerf Journal of Organic Chemistry, 1952 , vol. 17, p. 1425,1429

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H227-H315-H319-H335
Precautionary Statements : P210-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P403-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.1674
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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