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CS-W001157 4
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1-(2,3,4-Trifluorophenyl)ethan-1-one

  • CAS No. 243448-15-9

  • Cat. No. CS-0104908
  • Purity≥98%
  • MDL No.MFCD00061231

*For research and further manufacturing use only, not for direct human use.

1-(2,3,4-Trifluorophenyl)ethan-1-one|CS-0104908

Structure of 243448-15-9

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General Information

  • CAS No. 243448-15-9
  • Cat. No. CS-0104908
  • Purity ≥98%
  • MDL No. MFCD00061231
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅F₃O
  • Molecular Weight 174.12
  • Synonym(s) 2',3',4'-Trifluoroacetophenone
  • SMILES CC(C1=CC=C(F)C(F)=C1F)=O

Description

This trifluorophenyl ketone features a sterically accessible carbonyl group flanked by electron-deficient aromatic substituents, enabling efficient coupling in transition-metal-catalyzed cross-coupling reactions. The bench-stable scaffold integrates readily into complex molecular architectures under standard conditions.

Application

1-(2,3,4-Trifluorophenyl)ethan-1-one serves as a versatile building block in medicinal chemistry, enabling efficient construction of biologically relevant scaffolds. Its trifluorophenyl moiety imparts enhanced metabolic stability and lipophilicity, while the ketone group facilitates nucleophilic additions, reductive aminations, and coupling reactions. Bench-stable and readily purified by crystallization, it functions reliably in standard synthetic workflows for API intermediates and heterocycle synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.3065
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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