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CS-W001157 4
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(2,3-Dichlorophenyl)hydrazine hydrochloride

  • CAS No. 21938-47-6

  • Cat. No. CS-W014960
  • Purity≥97%
  • MDL No.MFCD00052265

*For research and further manufacturing use only, not for direct human use.

(2,3-Dichlorophenyl)hydrazine hydrochloride|CS-W014960

Structure of 21938-47-6

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General Information

  • CAS No. 21938-47-6
  • Cat. No. CS-W014960
  • Purity ≥97%
  • MDL No. MFCD00052265
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇Cl₃N₂
  • Molecular Weight 213.49
  • Synonym(s) 2,3-Dichloropheynylhydrazine hydrochloride
  • SMILES NNC1=CC=CC(Cl)=C1Cl.[H]Cl

Description

(2,3-Dichlorophenyl)hydrazine hydrochloride delivers a readily accessible hydrazine handle for constructing heterocyclic scaffolds in medicinal chemistry. The dichlorophenyl moiety imparts enhanced lipophilicity and metabolic stability, while the hydrochloride salt form ensures improved solubility and handling under standard conditions. This compound serves as a key intermediate in the synthesis of bioactive nitrogen-containing compounds.

Application

(2,3-Dichlorophenyl)hydrazine hydrochloride serves as a reliable building block for heterocyclic synthesis, particularly in the construction of pyrazole and triazole scaffolds. Its stability under ambient conditions and compatibility with standard coupling protocols enable efficient access to functionalized aromatic hydrazones. The molecule facilitates regioselective cyclizations and exhibits predictable reactivity in condensation reactions, making it a practical choice for medicinal chemistry campaigns requiring chlorinated aryl motifs.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P305+P351+P338-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.05
  • LogP   2.7008
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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