(R)-3-Ethylmorpholine hydrochloride

Name: (R)-3-Ethylmorpholine hydrochloride
Brand: ChemScene
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CAS No. 218785-38-7
Cat. No. CS-0146943
Molecule weight151.63
Purity≥95%
MDL No.MFCD18381949

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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(R)-3-Ethylmorpholine hydrochloride|CS-0146943

Structure of 218785-38-7

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General Information

CAS No. 218785-38-7
Cat. No. CS-0146943
Purity ≥95%
MDL No. MFCD18381949
Storage Store at room temperature, keep dry and cool
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₁₄ClNO
Molecular Weight 151.63
Synonym(s) (3R)-3-ethylmorpholine hydrochloride
SMILES CC[C@H]1NCCOC1.[H]Cl

Description

(R)-3-Ethylmorpholine hydrochloride is a chiral, bench-stable building block featuring a defined stereochemistry at the 3-position. This nitrogen-containing heterocycle combines enhanced solubility with predictable reactivity, enabling efficient incorporation into asymmetric synthesis workflows. The hydrochloride salt form ensures stability and ease of handling in standard laboratory protocols.

Application

(R)-3-Ethylmorpholine hydrochloride serves as a chiral building block for medicinal chemistry, enabling stereoselective synthesis of bioactive molecules. Its stable hydrochloride salt form offers excellent bench handling and solubility, facilitating use in standard amine functionalization, alkylation, and coupling reactions. Functions as a versatile scaffold in the construction of heterocyclic APIs and transition metal-catalyzed transformations.

Synthesis

Route1
- 1007113-30-5
- ~56%
- In-stock
  
  218785-38-7
References
- Medina, Jesus R.; Becker, Christopher J.; Blackledge, Charles W.; Duquenne, Celine; Feng, Yanhong; Grant, Seth W.; Heerding, Dirk; Li, William H.; Miller, William H.; Romeril, Stuart P.; Scherzer, Daryl; Shu, Arthur; Bobko, Mark A.; Chadderton, Antony R.; Dumble, Melissa; Gardiner, Christine M.; Gilbert, Seth; Liu, Qi; Rabindran, Sridhar K.; Sudakin, Valery; Xiang, Hong; Brady, Pat G.; Campobasso, Nino; Ward, Paris; Axten, Jeffrey M. Journal of Medicinal Chemistry, 2011 , vol. 54, # 6 p. 1871 - 1895

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 21.26
LogP 0.8066
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(R)-3-Ethylmorpholine hydrochloride

CAS No. 218785-38-7

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