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2-Methyl-2-phenylpropan-1-ol

  • CAS No. 2173-69-5

  • Cat. No. CS-0166813
  • Purity≥98%
  • MDL No.MFCD00506139

*For research and further manufacturing use only, not for direct human use.

2-Methyl-2-phenylpropan-1-ol|CS-0166813

Structure of 2173-69-5

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General Information

  • CAS No. 2173-69-5
  • Cat. No. CS-0166813
  • Purity ≥98%
  • MDL No. MFCD00506139
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₄O
  • Molecular Weight None
  • Synonym(s) 2-methyl-2-phenyl-propan-1-ol
  • SMILES OCC(C)(C)C1=CC=CC=C1

Description

2-Methyl-2-phenylpropan-1-ol is a tertiary alcohol featuring a sterically hindered benzylic center, offering enhanced stability and resistance to oxidation. This bench-stable compound serves as a valuable building block in asymmetric synthesis and organocatalysis, where its bulky aryl-substituted structure facilitates stereoselective transformations.

Application

2-Methyl-2-phenylpropan-1-ol serves as a stable, bench-ready tertiary alcohol scaffold for stereoselective transformations and as a key building block in the synthesis of chiral auxiliaries and pharmaceutical intermediates. Its tertiary hydroxyl group enables efficient conversion to halides or sulfonates under standard conditions, while the bulky phenyl-substituted carbon center provides steric protection and enhanced stability during purification. Functions reliably in Grignard additions, dehydration reactions, and as a precursor to biologically relevant motifs in medicinal chemistry workflows.

Synthesis

  • Route1

    References

    • Di Giacomo, Barbara; Coletta, Donato; Natalini, Benedetto; Ni, Ming-Hong; Pellicciari, Roberto Farmaco, 1999 , vol. 54, # 9 p. 600 - 610
  • Route2

    References

    • Yu, Zhoujie; Wang, Wei; Chen, Liqin Journal of Labelled Compounds and Radiopharmaceuticals, 2011 , vol. 54, # 7 p. 352 - 356
  • Route3

    References

    • Acharya; Joshi Pesticide Science, 1999 , vol. 55, # 8 p. 850 - 856

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   1.9565
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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