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CS-W001157 4
Total: USD 88.00

Cabozantinib impurity 6

  • CAS No. 5406-86-0

  • Cat. No. CS-W021395
  • Purity≥98%
  • MDL No.MFCD00236023

*For research and further manufacturing use only, not for direct human use.

Cabozantinib impurity 6|CS-W021395

Structure of 5406-86-0

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General Information

  • CAS No. 5406-86-0
  • Cat. No. CS-W021395
  • Purity ≥98%
  • MDL No. MFCD00236023
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₈O
  • Molecular Weight 178.28
  • Synonym(s) None
  • SMILES CC(C1=CC=C(CCO)C=C1)(C)C

Description

This bench-stable alcohol features a hydrophobic tert-butyl-phenyl moiety that enhances solubility in organic media. The ethanolic functionality enables straightforward derivatization, facilitating integration into complex synthetic sequences under standard conditions.

Synthesis

  • Route1
    • Methyl p-tert-butylphenylacetate, ≥97%|CS-1269593
      3549-23-3
    • ~96%
    • In-stock
      Cabozantinib impurity 6|CS-W021395
      5406-86-0

    References

    • Bodnar, Brian S.; Vogt, Paul F. Journal of Organic Chemistry, 2009 , vol. 74, # 6 p. 2598 - 2600
  • Route2

    References

    • Lanni Jr., Thomas B.; Greene, Keri L.; Kolz, Christine N.; Para, Kimberly S.; Visnick, Melean; Mobley, James L.; Dudley, David T.; Baginski, Theodore J.; Liimatta, Marya B. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 3 p. 756 - 760
  • Route3

    References

    • Lee, Jeewoo; Kim, Su Yeon; Park, Soyoung; Lim, Ju-Ok; Kim, Ji-Min; Kang, Myungshim; Lee, Jiyoun; Kang, Sang-Uk; Choi, Hyun-Kyung; Jin, Mi-Kyung; Welter, Jacqueline D.; Szabo, Tamas; Tran, Richard; Pearce, Larry V.; Toth, Attila; Blumberg, Peter M. Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 5 p. 1055 - 1069

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS08,GHS09
Signal Word : Danger
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H318-H361-H373-H411
Precautionary Statements : P260-P273-P280-P391-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.5189
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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