4-Bromo-3-chloro-1-methylpyridin-2(1H)-one

Name: 4-Bromo-3-chloro-1-methylpyridin-2(1H)-one
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 2172654-58-7
Cat. No. CS-0162927
Molecule weight222.47
Purity≥97%
MDL No.None

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Bromo-3-chloro-1-methylpyridin-2(1H)-one|CS-0162927

Structure of 2172654-58-7

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 2172654-58-7
Cat. No. CS-0162927
Purity ≥97%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₅BrClNO
Molecular Weight 222.47
Synonym(s) 4-Bromo-3-chloro-1-methyl-2(1H)-pyridinone
SMILES O=C1C(Cl)=C(Br)C=CN1C

Description

4-Bromo-3-chloro-1-methylpyridin-2(1H)-one features a densely functionalized pyridinone core with orthogonal halogen handles and a methyl group at the 1-position. This scaffold enables selective cross-coupling reactions under palladium catalysis, delivering complex heterocyclic architectures. The electron-deficient ring system enhances reactivity in nucleophilic substitution processes, while the bench-stable nature ensures reliable handling in synthetic workflows.

Application

4-Bromo-3-chloro-1-methylpyridin-2(1H)-one serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The bromo group facilitates efficient Suzuki and Buchwald–Hartwig transformations, while the chloro and methylpyridinone functionalities offer enhanced stability and compatibility with diverse functional groups. Its bench-stable nature and ease of purification make it ideal for multi-step synthesis of heterocyclic scaffolds and API intermediates.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 22
LogP 1.8012
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

2172654-58-7 sigma2172654-58-7 manufacturer2172654-58-7 price2172654-58-7 structure2172654-58-7 SDSbuy 2172654-58-72172654-58-7 supplier2172654-58-7 uses2172654-58-7 molecular weightprice of 2172654-58-72172654-58-7 chemical name formula of 2172654-58-7

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

4-Bromo-3-chloro-1-methylpyridin-2(1H)-one

CAS No. 2172654-58-7

Recommended Products