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tert-Butyl (trans-3-(methylamino)cyclobutyl)carbamate

  • CAS No. 2168236-44-8

  • Cat. No. CS-0433701
  • Purity≥95%
  • MDL No.MFCD31705838

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (trans-3-(methylamino)cyclobutyl)carbamate|CS-0433701

Structure of 2168236-44-8

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General Information

  • CAS No. 2168236-44-8
  • Cat. No. CS-0433701
  • Purity ≥95%
  • MDL No. MFCD31705838
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₂₀N₂O₂
  • Molecular Weight 200.28
  • Synonym(s) None
  • SMILES N(C(OC(C)(C)C)=O)[C@H]1C[C@H](NC)C1

Description

tert-Butyl (trans-3-(methylamino)cyclobutyl)carbamate features a rigid trans-cyclobutane scaffold bearing a methylamino substituent and a bench-stable carbamate protecting group. This configuration enables selective incorporation into complex molecular architectures, particularly in the development of constrained peptidomimetics and bioactive heterocycles where defined stereochemistry and metabolic stability are critical.

Application

tert-Butyl (trans-3-(methylamino)cyclobutyl)carbamate serves as a stable, bench-ready building block for the synthesis of bioactive cyclobutane-containing scaffolds. The trans-configured cyclobutyl core provides defined stereochemistry, while the tert-butyl carbamate group enables mild deprotection under acidic conditions. Its methylamino functionality offers direct access to diverse amine derivatives, facilitating rapid diversification in medicinal chemistry campaigns.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   50.36
  • LogP   1.2615
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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