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(2R,4R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-4-hydroxypyrrolidine-2-carboxylic acid

  • CAS No. 214852-45-6

  • Cat. No. CS-0089869
  • Purity≥95%
  • MDL No.MFCD01318735

*For research and further manufacturing use only, not for direct human use.

(2R,4R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-4-hydroxypyrrolidine-2-carboxylic acid|CS-0089869

Structure of 214852-45-6

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General Information

  • CAS No. 214852-45-6
  • Cat. No. CS-0089869
  • Purity ≥95%
  • MDL No. MFCD01318735
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₀H₁₉NO₅
  • Molecular Weight 353.37
  • Synonym(s) Fmoc-D-cis-hyp-OH
  • SMILES O=C(N1[C@@H](C(O)=O)C[C@@H](O)C1)OCC2C3=C(C4=C2C=CC=C4)C=CC=C3

Description

This fluorenylmethoxycarbonyl-protected pyrrolidine derivative features a stereodefined hydroxyl group at the C4 position, enabling direct incorporation into peptide synthesis. The bench-stable, moisture-tolerant scaffold facilitates efficient N-terminal functionalization in solid-phase and solution-phase workflows.

Application

(2R,4R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-4-hydroxypyrrolidine-2-carboxylic acid serves as a chiral building block for peptide synthesis and medicinal chemistry applications. The Fmoc group enables orthogonal protection, while the 4-hydroxy functionality provides a site for derivatization or incorporation into bioactive scaffolds. Bench-stable and readily purified by chromatography, it facilitates efficient coupling reactions in solid-phase and solution-phase workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   87.07
  • LogP   2.4553
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   3

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