(R)-2-Oxoimidazolidine-4-carboxylic acid

Name: (R)-2-Oxoimidazolidine-4-carboxylic acid
Brand: ChemScene
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CAS No. 214767-15-4
Cat. No. CS-0527049
Purity≥95%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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(R)-2-Oxoimidazolidine-4-carboxylic acid|CS-0527049

Structure of 214767-15-4

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General Information

CAS No. 214767-15-4
Cat. No. CS-0527049
Purity ≥95%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₆N₂O₃
Molecular Weight 130.10
Synonym(s) 4-Imidazolidinecarboxylicacid,2-oxo-,(4R)-(9CI)
SMILES O=C([C@@H](CN1)NC1=O)O

Description

(R)-2-Oxoimidazolidine-4-carboxylic acid is a chiral heterocyclic building block featuring a rigid imidazolidine core with a keto group at the 2-position and a carboxylic acid at the 4-position. This configuration imparts enhanced stability and defined stereochemistry, enabling its use in asymmetric synthesis and peptide mimetic design. The molecule integrates readily into bioactive scaffolds due to its polar functional groups and structural rigidity.

Application

(R)-2-Oxoimidazolidine-4-carboxylic acid serves as a versatile chiral building block in medicinal chemistry, enabling efficient access to imidazolidinone-containing scaffolds prevalent in kinase inhibitors and protease modulators. Its well-defined stereochemistry and functional group tolerance facilitate direct derivatization via amide coupling, reductive amination, or nucleophilic substitution, with excellent bench stability and straightforward purification by recrystallization or chromatography.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 78.43
LogP -1.2476
H_Acceptors 2
H_Donors 3
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Imidazolidin compounds

Key Words

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(R)-2-Oxoimidazolidine-4-carboxylic acid

CAS No. 214767-15-4

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