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CS-W001157 4
Total: USD 88.00

4,4,5,5-Tetramethyl-2-(4-(trifluoromethyl)phenyl)-1,3,2-dioxaborolane

  • CAS No. 214360-65-3

  • Cat. No. CS-0041248
  • Purity≥97%
  • MDL No.MFCD05863924

*For research and further manufacturing use only, not for direct human use.

4,4,5,5-Tetramethyl-2-(4-(trifluoromethyl)phenyl)-1,3,2-dioxaborolane|CS-0041248

Structure of 214360-65-3

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General Information

  • CAS No. 214360-65-3
  • Cat. No. CS-0041248
  • Purity ≥97%
  • MDL No. MFCD05863924
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₆BF₃O₂
  • Molecular Weight 272.07
  • Synonym(s) 4-Trifluoromethylphenylboronic acid pinacol ester
  • SMILES CC1(C)OB(OC1(C)C)C1=CC=C(C=C1)C(F)(F)F

Description

This boronate ester features a sterically shielded tetramethylcyclopentadienone core paired with a para-trifluoromethylphenyl group, enabling robust coupling in Suzuki-Miyaura reactions. The trifluoromethyl substituent imparts enhanced electron-withdrawing character and improved stability under standard conditions.

Synthesis

  • Route1

    References

    • Nagashima, Yuki; Takita, Ryo; Yoshida, Kengo; Hirano, Keiichi; Uchiyama, Masanobu Journal of the American Chemical Society, 2013 , vol. 135, # 50 p. 18730 - 18733
  • Route2
    • null|null
      98-56-6
    • In-stock
      Bis(pinacolato)diborane|CS-D1216
      73183-34-3
    • ~91%
    • In-stock
      4,4,5,5-Tetramethyl-2-(4-(trifluoromethyl)phenyl)-1,3,2-dioxaborolane|CS-0041248
      214360-65-3

    References

    • Chow, Wing Kin; Yuen, On Ying; So, Chau Ming; Wong, Wing Tak; Kwong, Fuk Yee Journal of Organic Chemistry, 2012 , vol. 77, # 7 p. 3543 - 3548
  • Route3
    • In-stock
      4-Iodobenzotrifluoride|CS-W004060
      455-13-0
    • null|null
      25015-63-8
    • ~%
    • In-stock
      4,4,5,5-Tetramethyl-2-(4-(trifluoromethyl)phenyl)-1,3,2-dioxaborolane|CS-0041248
      214360-65-3

    References

    • US6680401 B1, ; Page column 58 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H413
Precautionary Statements : P264-P270-P273-P330

Quality Control

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Computational Chemistry Data

  • TPSA   18.46
  • LogP   3.0046
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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