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(5-Fluoro-2,3-dihydrobenzofuran-4-yl)methanamine hydrochloride

  • CAS No. 2135600-87-0

  • Cat. No. CS-0132025
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(5-Fluoro-2,3-dihydrobenzofuran-4-yl)methanamine hydrochloride|CS-0132025

Structure of 2135600-87-0

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General Information

  • CAS No. 2135600-87-0
  • Cat. No. CS-0132025
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁ClFNO
  • Molecular Weight 203.64
  • Synonym(s) 1-(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methanamine hydrochloride
  • SMILES NCC1=C2CCOC2=CC=C1F.[H]Cl

Description

This bench-stable, moisture-tolerant amine features a fluorinated benzofuran scaffold that enhances metabolic stability and modulates electronic properties. The para-fluoro substitution improves target binding affinity while the hydrochloride salt ensures high solubility and ease of handling in synthetic workflows.

Application

(5-Fluoro-2,3-dihydrobenzofuran-4-yl)methanamine hydrochloride serves as a versatile building block for medicinal chemistry, enabling efficient access to bioactive heterocycles. The scaffold features a fluorinated dihydrobenzofuran core with a primary amine handle, offering excellent functional group tolerance and stability under standard synthetic conditions. It facilitates rapid diversification via amide coupling, reductive amination, and electrophilic substitution, making it well-suited for lead optimization campaigns in CNS and oncology drug discovery.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   1.6411
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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