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CS-W001157 4
Total: USD 88.00

(5-Fluoro-2,3-dihydrobenzofuran-4-yl)methanamine

  • CAS No. 1896262-04-6

  • Cat. No. CS-0132023
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(5-Fluoro-2,3-dihydrobenzofuran-4-yl)methanamine|CS-0132023

Structure of 1896262-04-6

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General Information

  • CAS No. 1896262-04-6
  • Cat. No. CS-0132023
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀FNO
  • Molecular Weight 167.18
  • Synonym(s) MONOFLUORIDE
  • SMILES NCC1=C2CCOC2=CC=C1F

Description

This bench-stable boronate moiety integrates a fluorinated dihydrobenzofuran scaffold, offering enhanced metabolic stability and favorable solubility. The para-fluoro substitution modulates electronic properties, while the primary amine enables direct coupling in cross-coupling reactions and conjugation workflows.

Application

(5-Fluoro-2,3-dihydrobenzofuran-4-yl)methanamine serves as a valuable building block in medicinal chemistry, enabling the synthesis of fluorinated heterocyclic scaffolds. Its pendant primary amine facilitates straightforward derivatization via amidation, alkylation, and reductive amination. The molecule exhibits good bench stability and functional group tolerance, supporting efficient incorporation into diverse API candidates and enabling rapid SAR exploration in target-directed campaigns.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H314
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   1.2193
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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