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tert-Butyl (tert-butoxycarbonyl)oxycarbamate

  • CAS No. 85006-25-3

  • Cat. No. CS-W018709
  • Molecule weight233.26
  • Purity≥97%
  • MDL No.MFCD00034797

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (tert-butoxycarbonyl)oxycarbamate|CS-W018709

Structure of 85006-25-3

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General Information

  • CAS No. 85006-25-3
  • Cat. No. CS-W018709
  • Purity ≥97%
  • MDL No. MFCD00034797
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₉NO₅
  • Molecular Weight 233.26
  • Synonym(s) tert-Butyl N-(tert-Butoxycarbonyloxy)carbamate
  • SMILES O=C(OC(C)(C)C)NOC(OC(C)(C)C)=O

Description

N,O-Di-Boc-hydroxylamine (N,O-Bis(tert-butoxycarbonyl)hydroxylamine) may be used for the synthesis of the following:5-lipoxygenase inhibitor LY280810hydroxylamineshydroxamic acids,

Application

tert-Butyl (tert-butoxycarbonyl)oxycarbamate serves as a robust, bench-stable carbamate protecting group for amines, enabling selective N-acylation and subsequent deprotection under mild acidic conditions. It functions reliably in peptide synthesis and medicinal chemistry workflows, offering excellent compatibility with diverse functional groups and facilitating straightforward purification due to its low polarity and volatility.

Synthesis

  • Route1

    References

    • Baillie, Lynn C.; Batsanov, Andrei; Bearder, John R.; Whiting, Donald A. Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 20 p. 3471 - 3478
  • Route2

    References

    • WO2013/59194 A1, ; Page/Page column 38 ;
  • Route3

    References

    • Journal of the American Chemical Society, , vol. 81, p. 955

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   73.86
  • LogP   2.3778
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   0

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