Thieno[2,3-b]pyridin-5-amine

Name: Thieno[2,3-b]pyridin-5-amine
Brand: ChemScene
Availability: InStock
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CAS No. 21344-28-5
Cat. No. CS-0054666
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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General Information

CAS No. 21344-28-5
Cat. No. CS-0054666
Purity ≥98%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₆N₂S
Molecular Weight 150.20
Synonym(s) Thieno[2,3-b]pyridin-5-amine (9CI)
SMILES S2C1=NC=C(C=C1C=C2)N

Description

Thieno[2,3-b]pyridin-5-amine features a fused thienopyridine core with a primary amine at the 5-position, enabling direct functionalization in cross-coupling and amide bond formation. This electron-rich heterocycle exhibits enhanced solubility and stability under standard bench conditions, facilitating its use in medicinal chemistry and materials synthesis.

Application

Thieno[2,3-b]pyridin-5-amine serves as a versatile heterocyclic building block in medicinal chemistry, featuring a fused thienopyridine core with a primary amine at the 5-position. The scaffold exhibits robust bench stability and functions effectively in Suzuki-Miyaura and Buchwald-Hartwig couplings, enabling efficient access to functionalized analogs. Its moderate basicity and favorable solubility profile support straightforward purification and integration into drug discovery workflows.

Synthesis

Route1
- 21344-35-4
- ~92%
- In-stock
  
  21344-28-5
References
- US2008/153860 A1, ; Page/Page column 25 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 38.91
LogP 1.8785
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Thiophene compounds

Key Words

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Thieno[2,3-b]pyridin-5-amine

CAS No. 21344-28-5

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